Using static and dynamic creep test the static and dynamic responses of creep stiffness modulus of asphalt mixtures for AC13 and AC25 with different gradations and asphalt-aggregate ratios determined by orthogonal test design,temperatures and loading levels were researched.The results show that influence of slight change of the gradations on the static and dynamic creep stiffness modulus of asphalt mixtures is significant. Whereas for the optimum asphalt-aggregate ratios when it is only a plus or minus 0.15%,little influence appears unless a severe departure from the optimum asphalt-aggregate ratios takes place.And increase of test temperatures results in a rapid decrease of the static and dynamic creep stiffness modulus of asphalt mixtures.However,the static creep stiffness modulus decreases but the dynamic creep stiffness modulus increases with rise of loading levels.Besides,the results also indicate that relationship between the static and dynamic creep stiffness modulus is well correlated under the same loading level.