Porous asphalt concrete with different material composition were studied by the fatigue test of stress control model, effect of air voids, asphalt aggregate ratio and saturation condition on the fatigue characteristic were investigated. The fatigue characteristics of porous asphalt concrete with different asphalt aggregate ratio and saturation time were compared by saturation fatigue tests. The results of the study show that the anti fatigue performance of porous asphalt concrete is decreased with the increase of the air voids; and the stress sensitivity of porous asphalt concrete was decreased as the value of asphalt aggregate ratio increased. There exist an optimum asphalt aggregate ratio which provides a best fatigue characteristic. Effects of saturation condition on the fatigue characteristic of porous asphalt concrete were closely related to the value of asphalt aggregate ratio, there will be only little influence when the value of asphalt aggregate ratio is moderate or larger.