By using elastic dynamics methods, the dynamic analysis model of the vacuum plate glass was built. The response characteristic of the vacuum plate glass under dynamic loading was calculated. The dynamic response characteristic of the vacuum plate glass was obtained through experiments. And the reasonability of the theoretical analysis method was verified by comparing the experimental results with theoretical analysis results. This provides important basis for monitoring of application, service life prediction and structural improvement design of the vacuum plate glass. The experimental results show that the dynamic response of the vacuum plate glass is enhanced to a maximum and then reduces with increasing the vibration frequency. The dynamic response of the vacuum plate glass reduces with the increase of the distance to the center of the vacuum plate glass. When external excitation frequeny reaches 50Hz, strong resonance phenomenon is observed in the vacuum plate glass. Normal operation properties of the vacuum plate glass are damaged, and its structural reliability and working stability is adversely affected.