With support of Xinjiang Guozigou Bridge project, the influence factor of the resistance to chloride ion permeation to the concrete bridge in alpine area was studied. The mechanism of resistance to chloride ion permeation to the concrete in different positions and with different composition of the bridge concrete was analyzed, then the mix design parameters for the bridge concrete that was suitable to built the bridge with resistance to chloride erosion were proposed. The result shows that the water binder ratio and water content have great effect on the resistance to chloride ion permeation to the concrete bridge. The water binder ratio of C30 grade of concrete is lowered from 045 to 039 and 56 days of electric flux for the concrete is reduced about 50%; electric flux for the concrete is decreased when the use level of fly ash increases from 10% to 30%; suitable air content can improve the resistance to chloride ion permeation to the concrete bridge.