The stiffness degradation rules of reinforced concrete(RC) frame and high performance fiber reinforced concrete(HPFRC) energy dissipation wall in RC frame HPFRC energy dissipation wall structure were studied. The lateral stiffness calculation model of RC frame HPFRC energy dissipation wall structure at cracking, yield and peak load points were established. The results show that the stiffness degradation rules of RC frame and HPFRC energy dissipation wall are quite different even at the same characteristic load point, and the stiffness degradation of HPFRC energy dissipation wall is much slower than that of RC frame; the lateral stiffness calculation model based on the stiffness degradation rules of HPFRC energy dissipation wall and RC frame basically reflects the mechanical properties and deformation characteristics of the structure, the calculated values of the lateral displacement of the structure based on the model are basically consistent with the test values.